• There is a considerable molecular genetic heterogeneity with

  2019-08-08

  

  There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions. Furthermore, for either gene fusion, additional heterogeneity stems from the location of the genomic breakpoints of the translocation, resulting in differen

• An important role for the precursor molecule of the main

  2019-08-08

  

  An important role for the precursor molecule of the main EBI2 ligand, 25-OHC, in the inhibition of inflammation was recently shown. 25-OHC was demonstrated to inhibit inflammasome induction in mouse macrophages [28]. Inflammasome assemblies are the sites of caspase 1 activation and lead to the gener

• Our results indicate an OT-specific

  2019-08-07

  Our results indicate an OT-specific activation of PKR that inactivates eIF2a and may, by this means, reduce protein translation by utilizing only select sensors and mediators of the UPR (i.e., avoiding significant PERK activation).

• G3DH has gained interest because

  2019-08-06

  G3DH has gained interest because of its broad substrate specificity and site-selective oxidation properties [9,10].

• Additionally, both in vitro and in vivo studies

  2019-08-05

  Additionally, both in vitro and in vivo studies showed that a Ca2+ influx is closely related to apoptosis (Rizzuto et al., 2003). Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells, which senses intracellular calcium levels by binding one Ca2+ ion.

• Six substrate recognition sites

  2019-08-02

  Six substrate recognition sites (SRS1-SRS6) have been identified at positions 102-123, 204-209, 238-244, 301-319, 374-382 and 483-492 (Table 2, underlined residues) based on Gotoh\'s proposal [30].

• Introduction Various researches

  2019-08-01

  Introduction Various researches have been made in the field of the treatment of cancer and inflammatory diseases.

• Although many neurotransmitters

  2019-07-31

  Although many neurotransmitters (e.g., catecholamines, serotonin, and excitatory/inhibitory amino acids) have been implicated in the modulation of anxiety-like responses

• In conclusion our work led to the

  2019-07-30

  In conclusion, our work led to the characterization of some signalling events of the CysLT1 receptor variants, at several levels, and showed that a punctual serine mutation could alter the response of receptors to cysLTs.

• In this study we have explored a functional

  2019-07-29

  In this study we have explored a functional role of the oxysterol/EBI2 system in this process. In 2011 we and others reported the discovery of oxysterols as ligands for EBI2 [6], [7].

• E1 protein was studied using

  2019-07-27

  E1 protein was studied using specific anti-E1 MEN 10376 in wild type cells and in transfected cells overexpressing the enzyme.

• CFSs are recognized as a driver of

  2019-07-26

  CFSs are recognized as a driver of genome instability in human cells and are hotspots for deletions or translocations in cancers (Richards, 2001).

• Introduction Ewing\'s sarcoma (EWS) is a bone

  2019-07-25

  Introduction Ewing\'s sarcoma (EWS) is a bone cancer arising mostly in children. In 1921, EWS was originally described as “diffuse endothelioma of bone” by Dr. James R. Ewing, an American pathologist [1].

• Cytokines as targets for the development

  2019-07-24

  Cytokines as targets for the development of drugs Since the first scientific evidence describing the large number of cytokines and their functional roles and involvement in molecular mechanism of various diseases or disorders researchers have targeted cytokines.

• The cysteinyl leukotrienes (cysLTs) LTC

  2019-07-23

  The cysteinyl leukotrienes (cysLTs) LTC, LTD, and LTE are increased in the airways of asthmatic subjects, with the ability to induce bronchoconstriction, vascular permeability, and mucus secretion.

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