• The positive correlation between ATG and

  2020-05-26

  

  The positive correlation between ATG7 and DCTPP1 (TCGA data) suggested our hypothesis that DCTPP1 may affect the phenotype of prostate tumor, or maybe other types of tumors as well, through its role in autophagy. To test this hypothesis, we carried out western-blot experiments in which the ratios of

• Of note CS associated lung injury is closely linked

  2020-05-26

  

  Of note, CS-associated lung injury is closely linked with augmented influx of macrophages that subsequently intensify the lung injury [34,47] while macrophage depletion alleviates CS-induced pulmonary inflammation via reducing cytokines and chemokine production in BALF [48]. Similar effect has been

• VHb expression in recombinant E coli expressing

  2020-05-26

  

  VHb expression in recombinant E. coli expressing P4H improved Hyp production, presumably by enhancing oxygen transfer. VHb expression contributed to improving growth and extending the period of exponential growth in both shaker flask culture and bioreactor fermentation. A similar phenomenon was also

• br Results and discussions In general

  2020-05-26

  

  Results and discussions In general, experimental analysis is time consuming and expensive. Thus, In the present study, Taguchi design of experiments (DOE) was adopted to reduce the number of trials. To analyze the data, a High Level Analysis (HLA) is performed by averaging measured data for each

• br Materials and methods br

  2020-05-26

  

  Materials and methods Results and discussion Concluding remarks Enzymatic production of bioactive 9-cis-11-trans-conjugated linoleic Oxaliplatin is part of a detoxification mechanism against linoleic acid which is a toxic and stress factor for many lactic bacteria such as Lactobacillus plan

• The monomeric oligomeric states of DDR V His and

  2020-05-26

  

  The monomeric/oligomeric states of DDR2-V5-His and DDR2-Fc were confirmed by Western blotting under reducing and non-reducing conditions. As shown in Fig. 1b, DDR2-V5-His exhibited a relative molecular mass of ~60 kDa under both reducing and non-reducing conditions, consistent with this protein bein

• br Materials and methods br Results

  2020-05-26

  

  Materials and methods Results Discussion In rodent species, CYP2E1 and CYP2B have been implicated in CCl4 metabolism. In this study, we used expressed human CYP2E1 to show that this enzyme is a high-affinity catalyst responsible for low-dose CCl4 metabolism. Studies employing an inhibitory

• Using HPLC and an amino acid sequencer the site

  2020-05-25

  

  Using HPLC and an amino tryptophan hydroxylase sequencer, the site of cleavage into the fluorogenic substrate AbzFRQEDDnp, determined as specific to the endopeptidase STH2, was analyzed and identified as being R2-Q3, and into substrate AbzFGQEDDnp, determined as specific to SH1, it was G2-Q3 (Fig. 5

• It has only recently been appreciated

  2020-05-25

  

  It has only recently been appreciated that antigen-activated TPPU mg undertake two additional transient migrations during the early stages of T-dependent antibody responses. In the first of these, antigen-activated B cells migrate rapidly (within 2–3h) to the outer regions of the follicle before th

• br Discussion The regulation of intracellular

  2020-05-25

  

  Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec

• Dgat mice however had less adipose tissue as reflected

  2020-05-25

  

  Dgat−/− mice, however, had less adipose tissue, as reflected by lower total fat pad weights and body triglyceride content. Because of these findings, we hypothesized that, although Dgat−/− mice could make triglycerides through non-DGAT pathway(s), their triglyceride synthesis capacity might not be e

• For the SAR optimization of the right hand side it

  2020-05-25

  

  For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic Biotin-azide receptor moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy linker was introduced

• The fibrillogenesis process of collagen is understood to ini

  2020-05-25

  

  The fibrillogenesis process of collagen is understood to initiate in the extracellular space near the plasma membrane where secretory vesicles form regions of deep invagination. However, it is not clear how and when collagen-binding proteins interact with collagen molecules during fibrillogenesis or

• In vitro work by us and others

  2020-05-25

  

  In vitro work by us and others revealed that high affinity interaction with collagen requires dimerization and/or pre-oligomerization of DDR1 (Agarwal et al., 2007, Abdulhussein et al., 2008, Leitinger, 2003). It has also been reported that a significant percentage of the DDR1 population forms ligan

• br Concluding remark br Acknowledgements

  2020-05-22

  

  Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human K-7174 mg daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within cancer cells

14511 records 810/968 page Previous Next First page 上5页 806807808809810 下5页 Last page