• Introduction Hepatocellular carcinoma HCC is the

  2022-05-12

  

  Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, Fosinopril sodium australia virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2], [3], [

• It is extremely difficult to predict a plausible conformer o

  2022-05-12

  

  It is extremely difficult to predict a plausible conformer of hsGCαβ heterodimer with right orientation of multiple domains. Even though the template identities in case of dimeric domains were not high enough but still we modelled the entire heterodimeric structure of hsGCαβ with a reasonable and ju

• br NO GC pathway and implications for

  2022-05-12

  

  NO-GC-1 pathway and implications for glaucoma Direct in vivo measurement of NO in the eye is not yet feasible. However, measurement of nitrate and nitrite levels are routinely used as markers for the activity of NOS and the production of NO radicals [98]. Several studies in human glaucoma patient

• SANT-1 The Rab to Rab switch on endosomes co occurs with

  2022-05-12

  

  The Rab5 to Rab7 switch on endosomes co-occurs with the release of the Rab5 GEF Rabex5 from endosomes, which prevents further Rab5 activation [5]. In addition, the Rab5 GAP is recruited to inactivate remaining Rab5 [67]. Recent data suggest that another GAP, TBC1D5, which binds the retromer complex,

• While PLGA implants could be

  2022-05-11

  

  While PLGA implants could be beneficial for regenerative angiogenesis in the context of wound healing, they Schizandrin A could also lead to adverse effects. Indeed, extracellular acidification inhibits osteoblast proliferation, differentiation, and extracellular matrix mineralization, which might

• With an ever increasing incidence rate of type diabetes and

  2022-05-11

  

  With an ever-increasing incidence rate of type 2 diabetes and obesity, it is imperative to develop new therapeutic regimes that may provide a benefit both in terms of efficacy and tolerability. The existing portfolio of drugs for the treatment of metabolic disorders, primarily type 2 diabetes and ob

• After the origin of the family of genes for

  2022-05-11

  

  After the origin of the family of genes for receptors for peptides similar to glucagon, the genes have not remained static. Not only have their sequences evolved, but also like peptides similar to glucagon (Irwin, 2001, Irwin, 2009, Irwin, 2012, Ng et al., 2010, Hwang et al., 2013), the numbers of g

• cAMP is a key secondary messenger which transduces extracell

  2022-05-11

  

  cAMP is a key secondary messenger which transduces extracellular signals at glucagon receptors to intracellular effector molecules. cAMP-protein kinase A (PKA) pathway increases the gene expression of enzymes including phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) whic

• Mometasone furoate br NLS and NES Mapping br

  2022-05-11

  

  NLS and NES Mapping Sequence Comparison of Gli NLSs—NLSs in ZF Domains Alignment of the Gli NLSs of representative metazoan animals suggests that the amino Mometasone furoate residues in the ZF domains are strongly conserved (Figure 4.2, Figure 4.3B). However, the length of the intervening am

• Although GLP has greater insulin releasing effects

  2022-05-11

  

  Although GLP-1 has greater insulin-releasing effects at pharmacological concentrations [10], it is apparent that the higher circulating concentrations of GIP combined with more pronounced increase in secretion following feeding make GIP the major physiological incretin [7], [11]. The peptide exerts

• br Therapeutic approaches exploiting Cx function Due

  2022-05-11

  

  Therapeutic approaches exploiting Cx43 function Due to their potential role in cancer metastasis, attempts have been made to alter connexin function to inhibit cancer growth. Therapeutic approaches include Cx43 peptide mimetics, Cx43 inhibitors, chemical agents capable of enhancing Cx43 function,

• Chitosan CS a deacetylated derivative of chitin was chosen

  2022-05-11

  

  Chitosan (CS), a deacetylated derivative of chitin, was chosen in this study due to its unique biological characteristics including biodegradability, biocompatibility, non-toxicity, and antimicrobial properties (Klossner, Queen, Coughlin, & Krause, 2008; Kong, Chen, Xing, & Park, 2010; Ravi Kumar, 2

• In soft agar colony formation assay transformed cells indica

  2022-05-11

  

  In soft agar colony formation assay, transformed ddr1 receptor indicate anchorage-independent growth and colony formation without attachment on the bottom of cell culture plate. This assay can investigate transformation and tumorigenic activities [24]. Our recent study showed that the long-term 5-F

• Earlier we have showed that tumor associated sFas

  2022-05-11

  

  Earlier we have showed that tumor associated sFas mRNA isoform profile and splicing factors expression levels in solid tumors do not correspond to profiles that are observed in cell lines [45]. In the present study, for the first time we show that Fas but not Rac1 pre-mRNA's alternative splicing is

• Mitochondrial is the main source for

  2022-05-11

  

  Mitochondrial is the main source for ROS and ATP generation, and the loss of mitochondrial membrane potential is involved in the alteration of mitochondrial metabolism and mitochondrial failure-induced cell death [33,34]. In this study, we showed that upregulated ZNF32 sustained mitochondrial membra

14394 records 414/960 page Previous Next First page 上5页 411412413414415 下5页 Last page